Recent Publications
L.R. Burcham, M.S. Akbari, N. Alhajjar, R.A. Keogh, J.N. Radin, T.E. Kehl-Fie, A.T. Belew, N.M El-Sayed, K.S. McIver, K.S. Doran. Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization. mBio. 2022 Jun 28;13(3):e0098522. doi: 10.1128/mbio.00985-22. Epub 2022 Jun 6.PMID: 35658538
J.S. Rom, Y. Le Breton, E. Islam, A.T. Below, N.M. El-Sayed, K.S. McIver (2022) Loss of ropE encoding the delta factor RNA polymerase impacts pathophysiology of the Streptococcus pyogenes M1T1 strain 5448. Microorganisms Aug 22;10:8;1686. PMID: 36014103.
J.K.K. Woo, K.S. McIver, M.J. Federle (2022) Carbon Catabolite Repression on the Rgg2/3 Quorum Sensing System in Streptococcus pyogenes is Mediated by PTSMan and Mga. Molecular Microbiology Feb;117(2):525-538. doi: 10.1111/mmi.14866. Epub 2022 Jan 3.PMID: 34923680.
J.S. Rom, M.S. Hart, K.S. McIver (2021) PRD-containing Virulence Regulators (PCVRs) in Pathogenic Bacteria. Frontiers in Cell Infection Microbiology Oct 19;11:772874. doi: 10.3389. PMID: 34747980.
F. Akhter, E. Womack, J.E. Vidal, Y. Le Breton, K.S. McIver, S. Pawar, and Z. Eichenbaum (2021) Hemoglobin Induces Early and Robust Biofilm Formation in Streptococcus pneumoniae by a Pathway that Involves comC but not the Cognate comDE Two-Component System. Infection and Immunity Mar 17;89(4):e00779-20. doi: 10.1128/IAI.00779-20. Print 2021 Mar 17.PMID: 33397818
L.R. Burcham, Y. Le Breton, J.N. Radin, B.L. Spencer, L. Deng, A. Hiron, M.R. Ransom, J.D.C. Mendonça, A.T. Belew, N.M. El-Sayed, K.S. McIver, T.E. Kehl-Fie, and K.S. Doran (2020) Identification of Zinc-dependent Mechanisms Used by Group B Streptococcus to Overcome Calprotectin-mediated Stress. mBio. Nov 10;11(6):e02302-20. doi: 10.1128/mBio.02302-20.PMID: 33173000
F. Akhter, E. Womack, J.E. Vidal,Y. Le Breton, and K.S. McIver, S. Pawar, and Z. Eichenbaum (2020) Hemoglobin Stimulates Vigorous Growth of Streptococcus pneumoniae and Shapes the Pathogen's Global Transcriptome. Scientific Reports. Sep 16;10(1):15202. doi: 10.1038/s41598-020-71910-1.PMID: 32938947
R.E. Braza, A.B. Silver, G.S. Sundar, S.E. Davis, A. Razi, E. Islam, M. Hart, J. Zhu, Y. Le Breton, and K.S. McIver (2020) Phosphotransferase Uptake and Metabolism of the beta-Glucoside Salicin Impact Group A Streptococcal Bloodstream Infection. Infection and Immunity Sep 18;88(10):e00346-20. doi: 10.1128/IAI.00346-20. Print 2020 Sep 18.PMID: 32719156
J.A. Freiberg , Y. Le Breton, J.M. Harro, D.L. Allison, K.S. McIver, and M.E. Shirtliff (2020) The Arginine Deiminase Pathway Impacts Antibiotic Tolerance During Biofilm-mediated Streptococcus pyogenes Infections, mBio. Jul 7;11(4):e00919-20. doi: 10.1128/mBio.00919-20.PMID: 32636245
Y. Le Breton, A.T. Belew AT, and K.S. McIver (2020) Protocols for Tn-seq Analysis in the Group A Streptococcus, Methods Molecular Biology 2020;2136:33-57. doi: 10.1007/978-1-0716-0467-0_4.PMID: 32430812
R.E. Braza, Y. Le Breton, and K.S. McIver (2019) The scfCDE Operon Encodes a Predicted ABC Importer Required for Fitness and Virulence During Group A Streptococcus Invasive Infection, Infection and Immunity, 87(12):e00613-19, DOI: 10.1128, PMID: 31591169.
R.J. Edgar, V.P. Hensbergen, A. Ruda, A.G. Turner, P. Deng, Y. Le Breton, N.M. El-Sayed, A.T. Belew, K.S. McIver, A.G. McEwan, A.J. Morris, G. Lambeau, M.J. Walker, J.S. Rush, K.V. Korotokov, G. Widmalm, N.M van Sorge, and N. Korotkova (2019) Genetic Insight into Antimicrobial Resistance Mechanism Uncovers a Glycerol Phosphate Modification on Streptococcal Rhamnose Polysaccharides. Nature Chemical Biology, 15(5): 463-471, DOI: 10.1038, PMID: 30936502.
V.P. Hensbergen, E. Movert, V. de Maat, Y. Le Breton, G. Lambeau, C. Payré, A. Henningham, V. Nizet, J.A.G. van Strijp, F. Carlsson, K.S. McIver, and N.M. van Sorge (2018) Streptococcal Lancefield Polysaccharides are Critical Cell Wall Determinants for Human Group IIA Secreted Phospholipase A2 to Exert its Bactericidal Effects, PLoS Pathogens, 14(10), DOI: 10.3389, PMID: 30321240.
G.S. Sundar, E. Islam, R.D. Braza, A.B. Silver, Y. Le Breton, and K.S. McIver (2018) Route of Glucose Uptake in the Group A Streptococcus Impacts SLS-Mediated Hemolysis and Survival in Human Blood, Frontiers in Cellular and Infection Microbiology, 8:71,DOI: 10.3389/fcimb.2018.00071, PMID: 29594067.
K.M. Valdes, G.S. Sundar, A.T. Belew, E. Islam, N.M. El-Sayed, Y. Le Breton, and K.S. McIver (2018) Glucose Levels Alter the Mga Virulence Regulon in the Group A Streptococcus,Scientific Reports,8(1):4971, PMID: 29563558.
Y. Le Breton, A.T. Belew, J.A. Freiberg, G.S. Sundar, E. Islam, J. Lieberman, M.E. Shirtliff, H. Tettelin, N.M. El-Sayed, and K.S. McIver (2017) Genome-wide Discovery of Novel M1T1 Group A Streptococcal Determinants Important For Fitness and Virulence During Soft-Tissue Infection, PLoS Pathogens, 13(8):e1006584, DOI:10.1371/ppat.1006584.
J.S. Rom, Y. Le Breton, E. Islam, A.T. Below, N.M. El-Sayed, K.S. McIver (2022) Loss of ropE encoding the delta factor RNA polymerase impacts pathophysiology of the Streptococcus pyogenes M1T1 strain 5448. Microorganisms Aug 22;10:8;1686. PMID: 36014103.
J.K.K. Woo, K.S. McIver, M.J. Federle (2022) Carbon Catabolite Repression on the Rgg2/3 Quorum Sensing System in Streptococcus pyogenes is Mediated by PTSMan and Mga. Molecular Microbiology Feb;117(2):525-538. doi: 10.1111/mmi.14866. Epub 2022 Jan 3.PMID: 34923680.
J.S. Rom, M.S. Hart, K.S. McIver (2021) PRD-containing Virulence Regulators (PCVRs) in Pathogenic Bacteria. Frontiers in Cell Infection Microbiology Oct 19;11:772874. doi: 10.3389. PMID: 34747980.
F. Akhter, E. Womack, J.E. Vidal, Y. Le Breton, K.S. McIver, S. Pawar, and Z. Eichenbaum (2021) Hemoglobin Induces Early and Robust Biofilm Formation in Streptococcus pneumoniae by a Pathway that Involves comC but not the Cognate comDE Two-Component System. Infection and Immunity Mar 17;89(4):e00779-20. doi: 10.1128/IAI.00779-20. Print 2021 Mar 17.PMID: 33397818
L.R. Burcham, Y. Le Breton, J.N. Radin, B.L. Spencer, L. Deng, A. Hiron, M.R. Ransom, J.D.C. Mendonça, A.T. Belew, N.M. El-Sayed, K.S. McIver, T.E. Kehl-Fie, and K.S. Doran (2020) Identification of Zinc-dependent Mechanisms Used by Group B Streptococcus to Overcome Calprotectin-mediated Stress. mBio. Nov 10;11(6):e02302-20. doi: 10.1128/mBio.02302-20.PMID: 33173000
F. Akhter, E. Womack, J.E. Vidal,Y. Le Breton, and K.S. McIver, S. Pawar, and Z. Eichenbaum (2020) Hemoglobin Stimulates Vigorous Growth of Streptococcus pneumoniae and Shapes the Pathogen's Global Transcriptome. Scientific Reports. Sep 16;10(1):15202. doi: 10.1038/s41598-020-71910-1.PMID: 32938947
R.E. Braza, A.B. Silver, G.S. Sundar, S.E. Davis, A. Razi, E. Islam, M. Hart, J. Zhu, Y. Le Breton, and K.S. McIver (2020) Phosphotransferase Uptake and Metabolism of the beta-Glucoside Salicin Impact Group A Streptococcal Bloodstream Infection. Infection and Immunity Sep 18;88(10):e00346-20. doi: 10.1128/IAI.00346-20. Print 2020 Sep 18.PMID: 32719156
J.A. Freiberg , Y. Le Breton, J.M. Harro, D.L. Allison, K.S. McIver, and M.E. Shirtliff (2020) The Arginine Deiminase Pathway Impacts Antibiotic Tolerance During Biofilm-mediated Streptococcus pyogenes Infections, mBio. Jul 7;11(4):e00919-20. doi: 10.1128/mBio.00919-20.PMID: 32636245
Y. Le Breton, A.T. Belew AT, and K.S. McIver (2020) Protocols for Tn-seq Analysis in the Group A Streptococcus, Methods Molecular Biology 2020;2136:33-57. doi: 10.1007/978-1-0716-0467-0_4.PMID: 32430812
R.E. Braza, Y. Le Breton, and K.S. McIver (2019) The scfCDE Operon Encodes a Predicted ABC Importer Required for Fitness and Virulence During Group A Streptococcus Invasive Infection, Infection and Immunity, 87(12):e00613-19, DOI: 10.1128, PMID: 31591169.
R.J. Edgar, V.P. Hensbergen, A. Ruda, A.G. Turner, P. Deng, Y. Le Breton, N.M. El-Sayed, A.T. Belew, K.S. McIver, A.G. McEwan, A.J. Morris, G. Lambeau, M.J. Walker, J.S. Rush, K.V. Korotokov, G. Widmalm, N.M van Sorge, and N. Korotkova (2019) Genetic Insight into Antimicrobial Resistance Mechanism Uncovers a Glycerol Phosphate Modification on Streptococcal Rhamnose Polysaccharides. Nature Chemical Biology, 15(5): 463-471, DOI: 10.1038, PMID: 30936502.
V.P. Hensbergen, E. Movert, V. de Maat, Y. Le Breton, G. Lambeau, C. Payré, A. Henningham, V. Nizet, J.A.G. van Strijp, F. Carlsson, K.S. McIver, and N.M. van Sorge (2018) Streptococcal Lancefield Polysaccharides are Critical Cell Wall Determinants for Human Group IIA Secreted Phospholipase A2 to Exert its Bactericidal Effects, PLoS Pathogens, 14(10), DOI: 10.3389, PMID: 30321240.
G.S. Sundar, E. Islam, R.D. Braza, A.B. Silver, Y. Le Breton, and K.S. McIver (2018) Route of Glucose Uptake in the Group A Streptococcus Impacts SLS-Mediated Hemolysis and Survival in Human Blood, Frontiers in Cellular and Infection Microbiology, 8:71,DOI: 10.3389/fcimb.2018.00071, PMID: 29594067.
K.M. Valdes, G.S. Sundar, A.T. Belew, E. Islam, N.M. El-Sayed, Y. Le Breton, and K.S. McIver (2018) Glucose Levels Alter the Mga Virulence Regulon in the Group A Streptococcus,Scientific Reports,8(1):4971, PMID: 29563558.
Y. Le Breton, A.T. Belew, J.A. Freiberg, G.S. Sundar, E. Islam, J. Lieberman, M.E. Shirtliff, H. Tettelin, N.M. El-Sayed, and K.S. McIver (2017) Genome-wide Discovery of Novel M1T1 Group A Streptococcal Determinants Important For Fitness and Virulence During Soft-Tissue Infection, PLoS Pathogens, 13(8):e1006584, DOI:10.1371/ppat.1006584.